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Gastric cancer and Helicobacter pylori: the bug, the host or the environment?

¹ Department of Histopathology, Faculty of Medicine, St Mary’s Campus, Imperial College, London, UK
² Department of Microbiology, Mid Essex Hospital NHS Trust, Broomfield Hospital, Chelmsford, Essex, UK
³ HPA Primary Care Unit, Microbiology Department, Gloucestershire Royal Hospital, Gloucester, UK

Correspondence to:
Dr M M Walker, Department of Histopathology, Faculty of Medicine, St Mary’s Campus, Imperial College, London W2 1PG, UK; mm.walker@imperial.ac.uk

Keywords: gastric cancer; Helicobacter pylori

The first 150 words of the full text of this article appear below.

Worldwide, gastric cancer is still a leading cause of cancer deaths. The association of Helicobacter pylori and gastric cancer is well established, and the bacterium was declared a class one carcinogen by the International Agency for Research on Cancer and the World Health Organisation in 1994. H pylori infection is responsible for 5.5% of all global cancers, 75% of non-cardia gastric cancer and lymphoma, and 65% of gastric cancers worldwide.¹

In 2005, Marshall and Warren were awarded the Nobel Prize for Medicine for their pioneering work on H pylori (in 1984) showing the association between this bacterium and gastritis and that antibiotics could cure peptic ulcers.² Parsonnet et al³ formally demonstrated the link to gastric cancer in 1991. However, although more than 50% of people worldwide are infected with H pylori, only a small percentage of those infected will have clinical complications, which include gastric and duodenal ulcers, precancerous . . . [Full text of this article]

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Postgrad. Med. J. 2008 84: 193-197. [Abstract] [Full Text] [PDF]