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Postgrad Med J 2001;77:562-569 ( September )

Review

Clinical implications of the specialised B cell response to polysaccharide encapsulated pathogens

C G Vinuesaa, C de Lucasb, M C Cookc

a MRC Centre for Immune Regulation, University of Birmingham Medical School, Edgbaston, Birmingham, UK, b Department of Paediatric Nephrology, Hospital San Rafael, Madrid, Spain, c Canberra Clinical School, University of Sydney and The Canberra Hospital, Woden, ACT, Australia

Correspondence to: Dr Matthew Cook, Canberra Clinical School, University of Sydney, PO Box 11, Woden, ACT, Australia, 2606 Matthew.Cook@act.gov.au

Submitted 23 January 2001; Accepted 6 March 2001

The first 150 words of the full text of this article appear below.

    Introduction

Polysaccharide encapsulated human pathogens


Table Removed (Available Only in the Full Text)

include meningococci, pneumococci, and Haemophilus influenzae type b. These bacteria have caused substantial morbidity and mortality in humans since antiquity and are still the third leading cause of death in the world today.1 They account for the majority of childhood mortality from lower respiratory tract infections in developing countries, and are responsible for most cases of bacterial meningitis worldwide. Although these bacteria are members of distinct genuses, clinically they share a predilection for causing invasive disease, especially in young children. This review discusses how the clinical features common to these infections, including the shared predispositions, reflect the special immune response to polysaccharides, which occur in encapsulated bacteria (box 1). In particular, production of antibodies is critical for host defence against these organisms. A description of the basic immune response is used to explain the rationale of diagnostic and preventive strategies for patients with increased susceptibility to . . . [Full text of this article]


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