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Effect of serum creatine kinase-MBmass on the early and hierarchical diagnosis of related artery reperfusion in acute myocardial infarction

¹ Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology QiLu Hospital Shandong University, Jinan 250012, China
² Department of Cardiology, Qianfoshan Hospital of Shandong Province, Jinan 250014, China

Correspondence to:
Correspondence to:
Professor Wei Zhang
Department of Cardiology, Shandong University QiLu Hospital, 250012, 107# West Wenhua Road, Jinan, China; professor-zhangwei{at}163.com

Aim: To evaluate creatine kinase-MBmass (CK-MBmass) for the early diagnosis of infarct-related artery (IRA) patency after thrombolysis and the hierarchical diagnosis of related artery reperfusion (RAR).

Patients and methods: CK-MBmass and creatine kinase-MBactivity (CK-MBactivity) were measured kinetically in 48 patients treated with thrombolysis and 96 patients treated with routine drugs.

Results: In the continuous-RAR (CRAR) group, the peak values of CK-MBmass and CK-MBactivity appeared at 12 h, the peak durations were maintained for 8 h before decreasing to normal at 42 h, which occurred more quickly than those values in the non-RAR (NRAR) group. In the temporary-RAR (TRAR) group, the peak values appeared at 12 h, but no significant differences were found between the TRAR and NRAR groups in the time that the peak durations lasted before decreasing to normal values. In the reobliteration group after RAR, the peak values appeared at 12 h, and the peak durations were maintained for 8 h. After returning to the normal, a second peak appeared, and the time required for the values to return to normal was prolonged significantly.

Conclusions: CK-MBmass could be used as an indicator of RAR after thrombolysis; and the kinetic changes of serum CK-MBmass could be used for the hierarchical diagnosis of RAR in acute myocardial infarction.

Abbreviations: AMI, acute myocardial infarction; CK, creatine kinase; CK-MB, creatine kinase-MB; CK-MBactivity, creatine kinase-MBactivity; CK-MBmass, creatine kinase-MBmass; CRAR, continuous-RAR; cTnI, cardiac troponin I; cTnT, cardiac troponin T; ECG, electrocardiogram; IRA, infarct-related artery; MEIA, microparticle enzyme immunoassay; NRAR, non-RAR; PTCA, percutaneous transluminal coronary angioplasty; RAR, related artery reperfusion; TIMI, Thrombolysis in Myocardial Infarction; t-PA, tissue plasminogen activator; TRAR, temporary-RAR