HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sundar, N. Articles by Swift, G. Search for Related Content PubMed PubMed Citation Articles by Sundar, N. Articles by Swift, G.

Clinical presentation and incidence of complications in patients with coeliac disease diagnosed by relative screening

Department of Gastroenterology, Llandough Hospital, Penarth, Cardiff, UK

Correspondence to:
Correspondence to:
Neela Sundar
Llandough Hospital, Department of Gastroenterology, Penlan Road, Penarth, Cardiff CF64 2XX, UK;neelasvu{at}yahoo.com

Background: There is an increased prevalence of coeliac disease (CD) among relatives of those with the disease.

Aims: To compare the clinical features in patients with CD detected via family screening with those in patients diagnosed routinely.

Methods: Information on screening was provided to relatives of patients. Those who wished to be screened were tested for endomysial and/or tissue transglutaminase antibodies. Duodenal biopsy was performed in those with positive antibodies. The clinical details of the relative screening group were compared with those of 105 patients diagnosed routinely.

Results: 183 relatives underwent screening, of whom 32 had positive serology, 24 had histology diagnostic of CD, six had normal biopsies and two declined duodenal biopsy. Patients in the relative screening group were younger with a median age of 33 years (range 17–72 years) compared to the routine group which had a median age of 54 years (range 25–88 years). In the relative screening group, there was a male preponderance (M:F ratio 16:8), anaemia at presentation was significantly less common (13% v 58%; p<0.001) and osteoporosis was less frequent (9% v 22%; p<0.244) compared with the routine group. 65% of the relative screening group had gastrointestinal symptoms or anaemia at diagnosis.

Conclusions: Patients detected by family screening are younger with a male preponderance, but fewer had anaemia and osteoporosis.

Abbreviations: CD, coeliac disease; CI, confidence interval; DEXA, dual energy x ray absorptiometry; ELISA, enzyme linked immunosorbent assay; EMA, endomysial antibody; GI, gastrointestinal; IgA, immunoglobulin A; TTG, tissue transglutaminase

Keywords: clinical features; coeliac disease; complications; osteoporosis; relative screening