Postgrad Med J

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
Postgraduate Medical Journal 2006;82:e27; doi:10.1136/pmj.2006.049809
Copyright © 2006 The Fellowship of Postgraduate Medicine
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correction (v83,p186)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krishnan, S G S
Right arrow Articles by Cobbs, R K
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krishnan, S G S
Right arrow Articles by Cobbs, R K

CASE REPORT

Falsely raised TSH levels due to human anti-mouse antibody interfering with thyrotropin assay

S G S Krishnan 1, R Pathalapati 2, L Kaplan 3, R K Cobbs 4,*

1 Department of Nephrology, Long Island Jewish Medical Center, New Hyde Park, New York, USA
2 Resident, Internal Medicine, Currently, Fellow in Nephrology, Metropolitan Hospital Center, New York, New York, USA
3 Department of Pathology, Bellevue Hospital, New York, New York, USA
4 Division of Endocrinology, Department of Internal Medicine, Metropolitan Hospital Center, New York, New York, USA

Correspondence to:
Correspondence to:
S G S Krishnan
Division of Kidney Diseases and Hypertension, Long Island Jewish Medical Center, 410 Lakeville Road, Suite 105, New Hyde Park, NY 11042, USA; sgskrishnan{at}hotmail.com

The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported. Laboratory evaluation showed high levels of thyroid-stimulating hormone (TSH). The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism. TSH remained persistently raised and the patient became thyrotoxic. Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances. TSH levels were normalised with the addition of mouse serum to the patient’s sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.

Abbreviations: TSH, thyroid-stimulating hormone; IgG, immuno-globulin G; HAMA, human anti-mouse antibody






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2006 The Fellowship of Postgraduate Medicine