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Is the paraneoplastic syndrome of inappropriate antidiuretic hormone secretion in lung cancer always attributable to the small cell variety?

¹ Beatson Oncology Centre, Glasgow, UK
² New Cross Hospital, Wolverhampton, UK

Correspondence to:
Correspondence to:
Dr L M Tho
Beatson Oncology Centre, Glasgow G11 6NT, UK; lyemuntho{at}hotmail.com

The syndrome of inappropriate antidiuretic hormone (SIADH) secretion is a well recognised paraneoplastic phenomenon and the vast majority are associated with small cell lung carcinoma. Rarely however, the non-small cell variety can sometimes be responsible and this report describes such an occurrence. Uniquely in this case, after chemotherapy the paraneoplastic SIADH improved in parallel with a tumour response and this has not been reported previously.

Abbreviations: SIADH, syndrome of inappropriate antidiuretic hormone secretion; NSCLC, non-small cell lung carcinoma; SCLC, small cell lung carcinoma

Keywords: syndrome of inappropriate antidiuretic hormone secretion; paraneoplastic; non-small cell lung carcinoma