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Gastrointestinal involvement in POEMS syndrome: a novel clinical manifestation

¹ Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey
² Department of Gastroenterology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey
³ Hacettepe University, Faculty of Medicine
⁴ Department of Medical Oncology, Hacettepe University, Faculty of Medicine
⁵ Department of Pathology, Hacettepe University, Faculty of Medicine

Correspondence to:
Correspondence to:
Dr S Köklü
Tp Fakültesi caddesi, 259/3, Mamak, Ankara, Turkey; gskoklu{at}yahoo.com

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is characterised by a rare multisystem disorder of unknown pathogenesis. Although its pathophysiology is not well understood, overexpression of proinflammatory cytokines has been implicated. Gastrointestinal system disorders have not been reported among the components of the syndrome. A case is reported of POEMS syndrome with gastrointestinal involvement shown by gastrointestinal endoscopy.

Keywords: POEMS syndrome; gastrointestinal involvement; Castleman’s disease