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Use of the single subject design for practice based primary care research

Correspondence to:
Correspondence to:
Dr J E Janosky
University of Pittsburgh, School of Medicine, Department of Family Medicine and Clinical Epidemiology, and the Center for Primary Care Community-Based Research, 3518 Fifth Avenue, Pittsburgh, PA 15261 USA; jej{at}pitt.edu

The use of a single subject research design is proposed for practice based primary care research. An overview of the rationale of the design, an introduction to the methodology, strengths, limitations, a sample of recent literature citations, a working example, and possible clinical applications are presented.

Keywords: single subject design; clinical trials; N-of-one; practice based research; small trials

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