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A woman who couldn’t speak: report of methotrexate neurotoxicity

¹ Respiratory Medicine, Glenfield General Hospital, Leicester, UK
² Haematology Department, Leicester Royal Infirmary, Leicester, UK

Correspondence to:
Correspondence to:
Dr C S Chapman
Haematology Department, Sandringham Building, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK; claire.chapman{at}uhl-tr.nhs.uk

The association between methotrexate therapy and idiosyncratic neurological complications is well recognised in children. This case illustrates the importance of considering the diagnosis of methotrexate toxicity in an adult patient with behavioural and speech disturbances, who received it by intrathecal route only and in whom the only indicator was an abnormal electroencephalographic study

Abbreviations: ALL, acute lymphoblastic leukaemia; MRI, magnetic resonance imaging

Keywords: acute lymphoblastic leukaemia; aphasia; methotrexate