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Management of traumatic brain injury: some current evidence and applications

Correspondence to:
Correspondence to:
Dr Arpan Guha
Walton Centre for Neurology and Neurosurgery and University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK; arpan1{at}yahoo.com

Traumatic brain injury remains a worldwide problem. Newer modalities in the management of such injuries include both drugs and therapeutic strategies. Continuing research in animal models has provided a better understanding of the pathophysiological processes that follow head injury, and this in turn has enabled workers to work on improved treatment targets. Although there are exciting and novel approaches emerging, there is no substitute for meticulous initial resuscitation. Additionally, some of the more well known management options are now better understood. These concepts are discussed in the article.

Abbreviations: CPP, cerebral perfusion pressure; EEG, electroencephalography; ICP, intracranial pressure; NABIS H (trials), National Acute Brain Injury Study: Hypothermia; NMDA, N-methyl-D-aspartate; PaCO₂, arterial partial pressure of carbon dioxide; P(a)O₂, (arterial) partial pressure of oxygen; TBI, traumatic brain injury

Keywords: trauma; brain injury