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Dramatic levodopa responsiveness of dystonia in a sporadic case of spinocerebellar ataxia type 3

Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Correspondence to:
Correspondence to:
Dr R Nandagopal
Department of Neurology, Sri Venkateswara Institute of Medical Sciences, Tirupati-517 507, Andhra Pradesh, India; rnandagopal{at}yahoo.com

A genetically confirmed case of spinocerebellar ataxia type 3 (SCA 3), presenting with disabling foot dystonia, peripheral neuropathy, and minimal cerebellar signs is reported. The dystonia improved dramatically with levodopa treatment in the absence of additional parkinsonian feature. A trial of levodopa for dystonia in SCA 3 may be of therapeutic benefit, at least in the initial stage of the disease.

Keywords: spinocerebellar ataxia type 3; Machado-Joseph disease; dystonia; peripheral neuropathy; levodopa

This article has been cited by other articles:

				A. M. Duenas, R. Goold, and P. Giunti Molecular pathogenesis of spinocerebellar ataxias Brain, June 1, 2006; 129(6): 1357 - 1370. [Abstract] [Full Text] [PDF]