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Prostate cancer management: (1) an update on localised disease

¹ Institute of Urology, London
² St George’s Hospital, London

Correspondence to:
Correspondence to:
Mr Simon R J Bott
Prostate Cancer Research Centre, Charles Bell House, 67 Riding House Street, London W1W 7EY, UK; simonrjbott{at}hotmail.com

ABSTRACT
Prostate cancer is receiving ever more publicity with the result that more men are having their prostate specific antigen checked and a greater proportion of men are diagnosed with potentially curable localised disease. Advances in the therapeutic modalities including radical surgery, external beam radiotherapy, and brachytherapy have reduced the incidence of side effects and now offer patients a choice of treatments depending on their tumour characteristics, age, and co-morbidity. A significant proportion of men do not need intervention and may be safely kept under a "watch and wait" policy. The use of genetic markers may in the future distinguish between patients most likely to benefit from radical therapy and those in who either palliation or observation is more appropriate. This review examines the potentially curative options, as well as expectant management, outlining the pros and cons of each. The use of adjuvant and neoadjuvant therapy is also discussed.

Keywords: prostate cancer; radical prostatectomy; external beam radiotherapy; brachytherapy; androgen ablation

Abbreviations: CI, confidence interval; EBRT, external beam radiotherapy; PSA, prostate specific antigen; TNM, tumour, nodes, and metastasis; UICC, Union Internationale Contre Cancer

This article has been cited by other articles:

				S R J Bott, A J Birtle, C J Taylor, and R S Kirby Prostate cancer management: (2) an update on locally advanced and metastatic disease Postgrad. Med. J., November 1, 2003; 79(937): 643 - 645. [Abstract] [Full Text] [PDF]