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Haemoglobin Marseille-Long Island and interpretation of HbA1c: which HbA1c result is the "right answer"?

Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand

Correspondence to:
Correspondence to:
Dr Florkowski;
chris.florkowski{at}cdhb.govt.nz

ABSTRACT
A woman was screened for diabetes using glycated haemoglobin (HbA1c). Vastly different results were obtained by high performance liquid chromatography (45%), immunoassay (2.9%), and affinity chromatography (4.2%) compared with the non-diabetic range of less than 6.4%. Mass spectral studies confirmed the presence a haemoglobin variant, haemoglobin Marseille-Long Island which had confounded interpretation by all methods.

Keywords: glycated haemoglobin; HbA1c; haemoglobin variants

Abbreviations: HbA1c, glycated haemoglobin; HPLC, high performance liquid chromatography

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